Brant Isakson

Steven awarded an American Heart Association Predoctoral Fellowship

Steven was awarded an American Heart Association (AHA) Predoctoral Fellowship this May for his collaborative research between the Columbus and Isakson laboratories. AHA funds research related to cardiovascular function and disease and stroke, or to related clinical, basic science, bioengineering or biotechnology, and public health problems. Steven aims to investigate the molecular basis for the regulation of eNOS function by alpha globin and the physiological impact this interaction has on blood pressure regulation.

Straub AC, Mutchler S, Billaud M, Mykhaylo A, Palmer L, Le TH, Somlyo AV, Columbus L, Isakson BE. Hemoglobin α/eNOS coupling in endothelium is required for nitric oxide scavenging during vasoconstriction. Arteriosclerosis, Thrombosis, and Vascular Biology 34:2594 – 2600 (2014).

Isakson and Columbus receive Ivy Foundation Grant

The Ivy Foundation Biomedical Innovation Grants awarded Isakson and Columbus $80,000 in funding to develop novel anti-hypertensive therapeutics that target the hemoglobin alpha and eNOS interaction that they discovered.
Read more about other awards at UVA Today

Butcher JT, Johnson T, Beers J, Columbus L, Isakson BE.Hemoglobin α in the blood vessel wall. Free Radical Biology & Medicine 73C:136 – 142 (2014).

Straub AC, Lohman AW, Billaud M, Johnstone SR, Dwyer ST, Lee MY, Bortz PS, Best AK, Columbus L, Gaston B, Isakson BE. Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature. 491:473-7 (2012).

Johnstone SR, Kroncke BM, Straub AC, Best AK, Dunn CA, Mitchell LA, Peskova Y, Nakamoto RK, Koval M, Lo CW, Lampe PD, Columbus L, Isakson BE. MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circulation Research 111:201-211 (2012).