Steven Successfully Defends his PhD Thesis.

On June 17th, 2019, Steven Keller became Dr. Steven Keller. He successfully defended his thesis entitled “Endothelial Alpha Globin Controls Nitric Oxide Signaling”. Dr. Steven Keller was a joint student between Dr. Brant Isakson and Linda.

Columbus Lab lands an NIH Maximizing Investigators’ Research Award

We received an NIH MIRA to continue our research investigating the structure, dynamics, and function of bacterial pathogen membrane proteins that hijack cell function. NIH established this award “to increase the efficiency of NIGMS funding by providing investigators with greater stability and flexibility, thereby enhancing scientific productivity and the chances for important breakthroughs.” The grant […]

Jen will be an Assistant Professor at Stockton University

Starting August 2019, Dr. Jennifer Martin will be an Assistant Professor of Chemistry at Stockton University. Dr. Martin has been working towards this goal since starting her PhD at UVA. At Stockton University, she will continue her research in membrane proteins and biochemistry of proteins function with undergraduate students. At UVA, she worked to develop […]

Jason Successfully Defends His PhD

Congratulations Jason!

NSF proposal funded

The Columbus lab proposal “Investigating the impact of lipid-protein interactions in membrane protein structure and conformational dynamics” was recently funded by the NSF!

Columbus Lab Summer 2018

Row 1: Katie Ahn, Nicole Swope, Linda Columbus Row 2: Jason Kuhn, Tracy Caldwell, Jennifer Martin Row 3: Katherine Lake, Steven Keller, Marissa Kieber

Ji Defends Her Distinguished Major Thesis

Congratulations Ji!

Marissa Successfully Defends Her PhD

Congratulations Marissa!

Nicole wins 3rd Place in the Department 3rd Year Ph.D. Student Poster Event

Congratulations to Nicole on winning 3rd place in the poster competition! Third place earns a certificate and a $250 award.

Tracy attends the Telluride School on Biomolecular Structure and Dynamics

Theory and Experiment organized by the Telluride Science Research Center and taught by Martin Blackedge, Teresa Head-Gordon, Ann McDermott, Art Palmer, and John Straub in beautiful Telluride, Colorado. There she learned how both solid and solution state NMR, as well as computational methods, can be used to study protein dynamics and the pros and cons […]

Tracy advances to candidacy!

On September 27th, Tracy passed her qualifying exam with flying colors. Her committee members were Lukas Tamm, David Cafiso, Owen Pornillos, and Isabelle Derre.

Linda and Marissa co-present at UNC Wilmington

On April 7, 2017, Linda and Marissa had a fun time visiting and presenting their science to the Department of Chemistry & Biochemistry at UNC Wilmington.

Ji receives an Ingrassia Family Echols Scholars Research Grant

Ji received a $2,000 Ingrassia Family Echols Scholars Research Grant that will support her independent research in our laboratory.

Nicole Swope recieves NSF Graduate Research Fellowship

Nicole has been awarded a 2017 NSF Graduate Research Fellowship. “The program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based master’s and doctoral degrees at accredited United States institutions.”  She is one of six UVA students to receive the award this year.

Lab members attend the 61st Annual Biophysical Society Meeting

Jennifer Martin and Marissa Kieber presented a poster entitled “Investigation of affinities and structures of membrane protein-protein interactions using comparable samples.” Steven Keller presented a poster entitled “Molecular Competitors of the Alpha Globin/eNOS Interaction”

Ji receives Harrison Undergradaute Research Award

Ji received an UVA Harrison Undergraduate Research Award which will pay for her research stipend over the summer. Read more

Tracy & Nicole attend NMRFAM Introductory Structure Determination Workshop

Tracy and Nicole spent a week at the University of Wisconsin at Madison at the National Magnetic Resonance Facility at Madison (NMRFAM) Introductory Structure Determination Workshop. There they learned the steps to solution NMR structural determination including backbone and sidechain assignment, TOCSY and NOE assignments, structural refinement, and structural validation. They also learned the newest […]

Tracy and Nicole awarded training grant fellowships

Congratulations to Tracy and Nicole! Tracy was selected for the Molecular Biophysics Training Grant and Nicole was selected for the Biotechnology Training Grant.

Dr. Ashton Brock and Dr. Jennifer Martin

May 2016, Jen and Ashton graduated with their PhD degrees. Ashton started a clinical chemistry postdoctoral position at UVA and Jen is staying in the lab for a year to work with Linda on revising Introductory Chemistry at UVA.

Steven awarded an American Heart Association Predoctoral Fellowship

Steven was awarded an American Heart Association (AHA) Predoctoral Fellowship this May for his collaborative research between the Columbus and Isakson laboratories. AHA funds research related to cardiovascular function and disease and stroke, or to related clinical, basic science, bioengineering or biotechnology, and public health problems. Steven aims to investigate the molecular basis for the […]

Postdoctoral positions available

The Department of Chemistry at the University of Virginia invites applications for a Postdoctoral Research Associate to perform research in the area of biophysical investigations of membrane proteins. This is a one-year appointment; however, the appointment may be renewed for two additional one-year terms, contingent upon available funding and satisfactory performance. Completion of the PhD […]

Columbus Lab Members Present at the 60th Annual Biophysical Society Meeting

Five graduate students from the Columbus Laboratory attended and presented at the 60th Annual Biophysical Society Meeting in Los Angeles on February 27th to March 2nd, 2016. Ashton Brock presented a poster entitled “Micelles and Bicelles as Membrane Mimics for Membrane Protein Characterization” with collaborators Svetlana Baoukina and Peter Tieleman. Steven Keller presented a poster […]

NIH RO1 Renewed

Our research focused on pathogen – host interactions continues to be funded by the NIH. Opa proteins from Neisseria gonorrhoeae and N. meningitidis pose an intriguing biological riddle: How can a structure that is tolerant of sequence diversity bind to the same family of receptors, and also provide receptor selectivity among the receptor variants? Opa […]

Shelby Lipes receives an Harrison Undergraduate Research Award

Shelby, a 3rd year undergraduate conducting research in the Columbus laboratory, received an Harrison Undergraduate Research Award to fund her research project this summer. She is one of 35 UVA students selected to receive the award. Her research focuses on understanding the physical properties of detergents and that influence the solubilization, fold and function of […]

Columbus Lab Members Presents at the 59th Annual Meeting of the Biophysical Society

Four graduate students attended the 2015 Annual Biophysical Society Meeting in Baltimore on Febreuary 7-11. Jennifer Martin presented a platform talk entitled Insights into the Specificity of Neisserial Opa Protein Interactions with Human Receptors. Ashton Brock presented a poster entitled Systematic Perturbations of Micelle Properties to Investigate the Stabilization of Membrane Protein Structure and Function. […]

Isakson and Columbus receive Ivy Foundation Grant

The Ivy Foundation Biomedical Innovation Grants awarded Isakson and Columbus $80,000 in funding to develop novel anti-hypertensive therapeutics that target the hemoglobin alpha and eNOS interaction that they discovered. Read more about other awards at UVA Today

Research from the Columbus Lab featured on cover of JACS

Opa proteins are outer membrane proteins in Neisseria meningitidis and Neisseria gonorrhoeae that have flexible extracelullar loops that interact with human receptors. This Opa-receptor interaction triggers the engulfment of the bacterium by human host cells. The cover shows several conformers of these loops extending from the Opa β-barrel which is embedded in a lipid bilayer. […]

Ryan Lo and Ryan Oliver are now Dr. Lo and Dr. Oliver

On May 18, 2014, Ryan Oliver and Ryan Lo received their PhD at the Chemistry Graduation Ceremony. They successfully defended their theses earlier in the Spring semester. Dr. Ryan Lo’s thesis entitled “Spectroscopic Studies of Membrane Protein Structure, Dynamics, and Function” focused on investigations of Opa proteins involved in the engulfment of Neisseria gonorrhoeae. Dr. […]

Nana, Shelby, Jessica, and Sebastien Receive Undergraduate Summer Fellowships

All four undergraduates in the Columbus Laboratory received 2014 Summer Research Fellowships. Nana and Shelby received a Bass Scholarship from the Chemistry Department. Sebastien received a a 2014 nanoSTAR Undergraduate Summer Research Award. Jessica Yoo received a a 2014 CSS Summer Research Stipend.

Jen Presents a Poster at the Protein Transport Across Cell Membranes Gordon Research Conference

Jen presented a poster entitled “Neisseria Opa protein interactions with human receptors in vitro and in vivo” at the Protein Transport Across Cell Membranes Gordon Research Conference in Gavelston Texas on March 9-14, 2014. The poster described her thesis work in collaboration with the Criss laboratory.

Tsega receives 2014 Dolphus E. Milligan Fellowship

Tsega was accepted into the University of Maryland, College Park Chemistry and Biochemistry PhD program. She received the 2014 Dolphus E. Milligan Fellowship Award through a competitive process that included a 30 minute oral presentation. The award includes a two-year research assistant fellowship and a summer internship at the National Institute of Standards and Technology […]

Ashton Brock and Ryan Lo present at the 58th Annual Meeting of the Biophysical Society

Linda, Ryan, and Ashton attended the 58th Annual Meeting of the Biophysical Society in San Francisco on February 15 – 19, 2014 Ryan presented a poster entitled “Structure, dynamics and receptor binding of Opa proteins” on Monday afternoons poster session. Ashton presented a platform talk entitled “Influence of detergent properties on the solubilization and purification […]

Linda receives the Virginia Outstanding Faculty Award

The Outstanding Faculty Awards are the Commonwealth’s highest honor for faculty at Virginia’s public and private colleges and universities. These awards recognize superior accomplishments in teaching, research, and public service. See the articles in UVA Today and Cavalier Daily.

Columbus Lab Undergraduates Present at SURC 2014

On Thursday, January 30th, The Columbus Lab undergraduates drove to the University of Tennessee in Knoxville to attend the 46th Southeast Undergraduate Research Conference. Graduate students, Ashton Brock and Jennifer Martin and Linda joined them for the adventure. Nana Bosomtwe presented a poster entitled Thermophilic Coupling Enzymes: Enabling Functional Studies at Physiological Temperatures and was […]

Lab Celebrates Tenure at Snowshoe

A few years ago, Linda signed a document that said if she earned tenure she would bring the lab on a ski trip. In August, Linda was tenured so we headed to Snowshoe, WV on December 13th, 2013. Brett, Michelle, and Ingrid came from Nashville, TN and Alison and Georgine came from Salisbury, MD and […]

Ono and Oliver attend the 246th ACS National Meeting

Ryan and Tomihiro attended the 246th American Chemical Society National Meeting in Indianapolis, Indiana on September 8-12, 2013. Tomihiro was accepted to the Physical Chemistry Symposium Workshop for Undergraduate Chemistry Majors and presented his poster entitled “Modulating detergent micelle fluidity for membrane protein structural studies”.

Fox and Columbus paper highlighted in Protein Science

Solution NMR resonance assignment strategies for β-barrel membrane proteins published this month in Protein Science was highlighted “In This Issue” by the journal.

Dan Fox passes his thesis defense and graduates

April 10, 2013 The day of the defense May 19, 2013 Graduation

Linda receives UVA All-University Teaching Award

The UVA All-University Teaching Award is given for excellence in teaching with additional emphasis on research and service accomplishments. Nine awards were given each year to faculty through-out the University. Read more about this years awardees.

Ashton and Ryan present at the 2013 Huskey Research Exhibition

Ashton Brock presented a poster entitled “Influence of detergents on the solubilization and function of lipoprotein signal peptidase A: Connecting detergent and membrane protein physical properties” and was awarded 1st prize in the Physical Sciences and Mathematics Division. Ryan Oliver presented a poster entitled “Modulating the physical properties of micelles using detergent mixtures for membrane […]

Lab snow tubing trip

The lab headed to Wintergreen for snow tubing fun on March 11, 2013.

Ashton & Jen Advance to PhD Candidacy

Last week Jen & Ashton passed their second year qualifying exams and advanced to PhD Candidacy. They worked hard to prepare and the did extremely well!

Ryan, Ryan, and Linda attend the FASEB Conference: Molecular Biophysics of Membranes in Snowmass, CO

This years FASEB Conference: Molecular Biophysics of Membranes was in Snowmass, CO and The University of Virgina was well represented with the Kasson, Tamm, Wiener, and Columbus laboratories represented. Ryan Oliver and Ryan Lo presented posters entitled “Modulating the physical properties of micelles using binary detergent mixtures for future membrane protein investigations” and “Effects of […]

Ashton & Jen selected for NIH Funded UVA Training Grants

Ashton received the Molecular Biophysics Training Grant. he Predoctoral Molecular Biophysics Training Program is oriented toward providing a strong biophysics-related training environment that supplements the basic degree requirements and goals of the degree-granting departments within the University of Virginia. Jen received the Cell and Molecular Biology(CMB)training grant.The Cell and Molecular Biology faculty at the University […]

Alison & Brett Graduate

On May 20th, 2012, Alison and Brett received their PhD degrees and were hooded by Linda.