Jacqueline Hodges

Medical Student at Tufts

Chemistry major with biochemistry focus
Distinguished Major Program

As an undergraduate, Jackie investigated the direct binding of OpaHS (Opa50) to heparansulfate proteoglycan receptors (HSPGs) using fluorescence techniques and heparin, a structural analog of HSPGs. She aims to confirm a selective interaction between this membrane protein and the host receptor and quantify the binding affinity. Further understanding of the intrinsic protein and receptor properties that determine this selectivity will enhance studies of the protein-triggered engulfment of the pathogens.