Low q Bicelles are Mixed Micelles

Bicelles are used in many membrane protein studies as they are thought to be more bilayer-like than micelles. We investigated the properties of “isotropic” bicelles by SANS, SAXS, fluorescence anisotropy, and MD. All data suggest that bicelles with a q-value below 1 deviate from the classic bicelle which contains lipids in the core and detergent in the rim. Thus, not all isotropic bicelles are bilayer-like.

Low q Bicelles are Mixed Micelles.
Caldwell T, Baoukina S, Brock AT, Oliver RC, Root KT, Kreuger JK, Glover KJ, Tieleman DP, Columbus L.
J Phys Chem Lett. 2018 Jul 19. doi: 10.1021/acs.jpclett.8b02079. [Epub ahead of print]