Research

Inc proteins

Two models for IncA dimerizationChlamydiae are obligate intracellular bacteria that depend upon the metabolic activities of a host cell for survival and reproduction. These bacteria reside in membrane-bound vesicular niches termed inclusions that ultimately communicate with host exocytic trafficking to evade detection. Inclusion membrane proteins (Inc proteins) are a class of Chlamydiae proteins that reside in the inclusion membrane. To a large degree, the functions of these proteins are unknown. However, fusogenic studies have determined that IncA of C. trachomatis functions to facilitate homotypic fusion events between adjacent inclusions. The Columbus laboratory is investigating the structure of IncA.
— Tracy Caldwell and Katie Ahn