Lipid - Protein Interactions

How is the structure of a membrane protein impacted by the lipid environment? Specifically, is a structure stabilized by the presence of a lipid boundary?

To answer these question, TM0026 serves as a model polytopic helical membrane protein, We use NMR and EPR spectroscopy, as well as other biophysical approaches, to monitor tertiary and secondary structure in different, titratable lipid environments. This model system also allows us to identify and quantify the driving forces important in membrane protein fold and stability.

We are also interested in investigating if membrane proteins have evolved with the different lipid environments across bacterial species.