Lipid - protein interactions

How is the structure of a membrane protein impacted by the lipid environment? Specifically, is a structure stabilized by the presence of a lipid boundary?

To answer these question, TM0026 serves as a model polytopic helical membrane protein, We use NMR and EPR spectroscopy, as well as other biophysical approaches, to monitor tertiary and secondary structure in different, titratable lipid environments. This model system also allows us to identify and quantify the driving forces important in membrane protein fold and stability.

We are also interested in investigating if membrane proteins have evolved with the different lipid environments across bacterial species. 

Call

T: (434) 924-3241 

Follow us  

© 2020 by The Columbus Lab.

 Proudly created with Wix.com

The Columbus Lab is committed to a diverse and inclusive multidisciplinary research culture that enables lab members to obtain individual success, advance our research outcomes, and mentor and train the next generation of scientists. All members of the Columbus Lab contribute to an environment that values and respects all individuals and their unique perspectives. A scientific and laboratory culture where everyone feels they belong is our priority and critical to scientific advancement.

  • Twitter Clean