Research in the Columbus laboratory focuses on investigating the biophyscial driving forces that determine membrane protein stability, structure, dynamics, and interactions with lipids and other proteins. We utilize and develop many techniques to identify and quantify these forces.

We are particularly interested in bacterial membrane proteins that interact with host proteins or are novel antibiotic targets.


Lipid-Protein Interactions



Image by Nathan Dumlao



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The Columbus Lab is committed to a diverse and inclusive multidisciplinary research culture that enables lab members to obtain individual success, advance our research outcomes, and mentor and train the next generation of scientists. All members of the Columbus Lab contribute to an environment that values and respects all individuals and their unique perspectives. A scientific and laboratory culture where everyone feels they belong is our priority and critical to scientific advancement.

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