Columbus Labs

The research aims of the Columbus laboratory are two-fold:

  1. To understand the physical interactions between membrane proteins and lipids or membrane mimics

  2. To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins

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The Columbus Lab is committed to a diverse and inclusive multidisciplinary research culture that enables lab members to obtain individual success, advance our research outcomes, and mentor and train the next generation of scientists. All members of the Columbus Lab contribute to an environment that values and respects all individuals and their unique perspectives. A scientific and laboratory culture where everyone feels they belong is our priority and critical to scientific advancement.

Recent Publications

  • Refinement of Highly Flexible Protein Structures using Simulation-Guided Spectroscopy»

    Highly flexible proteins present a special challenge for structure determination because they are multi-structured yet not disordered, so their conformational ensembles are essential for understanding function. Because spectroscopic measurements of multiple conformational populations often provide sparse data, experiment selection is a limiting factor in conformational refinement. A molecular simulations- and information-theory based approach to select […]