Columbus Labs

The research aims of the Columbus laboratory are two-fold:

  1. To address the challenges in membrane protein structural biology

  2. To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins.

Specifically, the structures of neisserial Opa proteins, which interact with host proteins and are directly involved in bacterial pathogenesis, are of interest.

However, in order to investigate the structure of these proteins, as well as the complexes with the host receptors, methods for accelerating structure determination are being developed. [Read more→]

Recent Publications

  • Tuning micelle dimensions and properties with binary surfactant mixtures»

    Ryan C. Oliver, Jan Lipfert, Daniel A. Fox, Ryan H. Lo, Justin J. Kim, Sebastien Doniach, and Linda Columbus. Langmuir. 30(44):13353-61 (2014) Detergent micelles are used in many areas of research and technology, in particular as mimics of the cellular membranes in the purification and biochemical and structural characterization of membrane proteins. Applications of detergent [...]