To address the challenges in membrane protein structural biology
To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins.
Specifically, the structures of neisserial Opa proteins, which interact with host proteins and are directly involved in bacterial pathogenesis, are of interest.
However, in order to investigate the structure of these proteins, as well as the complexes with the host receptors, methods for accelerating structure determination are being developed. [Read more→]
Daniel A. Fox, Per Larsson, Ryan H. Lo, Brett M. Kroncke, Peter M. Kasson, and Linda Columbus The structure and dynamics of Opa proteins, which we report herein, are responsible for the receptor-mediated engulfment of Neisseria gonorrheae or Neisseria meningitidis by human cells and can offer deep understanding into the molecular recognition of pathogen–host receptor [...]