Columbus Labs

The research aims of the Columbus laboratory are two-fold:

  1. To understand the physical interactions between membrane proteins and lipids or membrane mimics

  2. To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins

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The Columbus Lab is committed to a diverse and inclusive multidisciplinary research culture that enables lab members to obtain individual success, advance our research outcomes, and mentor and train the next generation of scientists. All members of the Columbus Lab contribute to an environment that values and respects all individuals and their unique perspectives. A scientific and laboratory culture where everyone feels they belong is our priority and critical to scientific advancement.

Recent Publications

  • The Fluidity of Phosphocholine and Maltoside Micelles and the Effect of CHAPS.»

    The dynamics of phosphocholine and maltoside micelles, detergents frequently used for membrane protein structure determination, were investigated using electron paramagnetic resonance of spin probes doped into the micelles. Specifically, phosphocholines are frequently used detergents in NMR studies, and maltosides are frequently used in x-ray crystallography structure determination. Beyond the structural and electrostatic differences, this study […]