Columbus Labs

The research aims of the Columbus laboratory are two-fold:

  1. To address the challenges in membrane protein structural biology

  2. To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins.

Specifically, the structures of neisserial Opa proteins, which interact with host proteins and are directly involved in bacterial pathogenesis, are of interest.

However, in order to investigate the structure of these proteins, as well as the complexes with the host receptors, methods for accelerating structure determination are being developed. [Read more→]

Recent Publications

  • Endothelial nitric oxide synthase in the microcirculation»

    Endothelial nitric oxide synthase in the microcirculation Shu X, Keller TC 4th, Begandt D, Butcher JT, Biwer L, Keller AS, Columbus L, Isakson BE. Cellular and Molecular Life Sciences Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide (NO)–a key molecule that can directly (or indirectly) act as a vasodilator and anti-inflammatory […]