To address the challenges in membrane protein structural biology
To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins.
Specifically, the structures of neisserial Opa proteins, which interact with host proteins and are directly involved in bacterial pathogenesis, are of interest.
However, in order to investigate the structure of these proteins, as well as the complexes with the host receptors, methods for accelerating structure determination are being developed. [Read more→]
M. Brittany Johnson, Louise M. Ball, Kylene P. Daily, Jennifer N. Martin, Linda Columbus and Alison K. Criss. Opa+ Neisseria gonorrhoeae has reduced survival in human neutrophils via Src family kinase-mediated bacterial trafficking into mature phagolysosomes Cellular Microbiology.17:648-665 (2015) During gonorrhoeal infection, there is a heterogeneous population of Neisseria gonorrhoeae (Gc) varied in their expression [...]