To address the challenges in membrane protein structural biology
To investigate the structural determinants of bacterial pathogen - host interactions mediated by membrane proteins.
Specifically, the structures of neisserial Opa proteins, which interact with host proteins and are directly involved in bacterial pathogenesis, are of interest.
However, in order to investigate the structure of these proteins, as well as the complexes with the host receptors, methods for accelerating structure determination are being developed. [Read more→]
Carcino-embryonic antigen-like cellular adhesion molecules (CEACAMs), members of the immunoglobulin superfamily, are responsible for cell-cell interactions and cellular signaling events. Extracellular interactions with CEACAMs have the potential to induce phagocytosis, as is the case with pathogenic Neisseria bacteria. Pathogenic Neisseria species express opacity-associated (Opa) proteins, which interact with a subset of CEACAMs on human cells, […]